Proteases - ADAMs - Inward Rectifier Potassium (Kir) Channels - Chymotrypsin - cysteine protease
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A4436 GI 254023X2 CitationTarget: ADAMsSummary: ADAM10金属蛋白酶抑制剂
- A8162 E-64-c中文名: 阿洛司他丁酸Target: cysteine proteaseSummary: 半胱氨酸蛋白酶抑制剂
- A4033 Glimepiride中文名: 格列美脲Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 磺酰脲类化合物
- A2574 Aprotinin1 Citation中文名: 抑酶肽Target: Trypsin|Chymotrypsin|Kallikrein|TrypsinogenSummary: 牛胰蛋白酶抑制剂