Neuroscience - Histamine receptors - Dopamine receptor - Gap Junctions - 5-HT1 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1045 Gap 274 CitationTarget: Gap JunctionsSummary: 缝隙连接阻断剂
- A1044 Gap 268 CitationTarget: Gap JunctionsSummary: 间隙连接阻断肽,对应于connexin 43的63-75 aa。
- B4981 SumatriptanTarget: 5-HT1 ReceptorsSummary: 5-HT1受体激动剂
- B6457 8-Hydroxy-PIPAT oxalateTarget: 5-HT1 ReceptorsSummary: 5-HT1A受体激动剂
- B6337 8-Hydroxy-DPAT hydrobromideTarget: 5-HT1 ReceptorsSummary: 5-HT1A激动剂
- B1572 LatrepirdineTarget: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptorSummary: 脑细胞死亡抑制剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂
- B2232 Aripiprazole中文名: 阿立哌唑Target: 5-HT1 ReceptorsSummary: 5-HT受体部分激动剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂