Neuroscience - ETA Receptors - 5-HT1 Receptor - D2 Receptors - NMDA Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B1488 Pramipexole中文名: 普拉克索Target: D2 Receptors|D3 Receptors|D4 ReceptorsSummary: 多巴胺激动剂
- B1485 Pergolide mesylate中文名: 甲磺酸培高利特Target: D1 and D5 Receptors|D2 ReceptorsSummary: 多巴胺能激动剂
- B2251 Naratriptan中文名: 盐酸那拉曲坦,盐酸纳拉曲坦Target: 5-HT1 ReceptorSummary: 选择性5-HT1受体亚型激动剂
- B2007 Pizotifen Malate中文名: 苹果酸苯噻Target: 5-HT2 Receptors|D2 ReceptorsSummary: 5-HT受体拮抗剂
- B1477 Lurasidone HCl中文名: 盐酸鲁拉西酮Target: 5-HT2 Receptors|D2 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺D2/5-HT2A/5-HT7/5-HT1A抑制剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂
- B2240 Olanzapine中文名: 奥氮平Target: 5-HT2 Receptors|D2 ReceptorsSummary: 5-HT2A和多巴胺D2受体的拮抗剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂
- B2075 Ambrisentan中文名: 安贝生坦Target: ETA ReceptorsSummary: ETA受体拮抗剂