Neuroscience - DREADD Ligands - M3 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1607 Otilonium Bromide中文名: 奥替溴铵Target: M3 ReceptorsSummary: AChR抑制剂
- B1600 Darifenacin HBr中文名: 氢溴酸达非那新Target: M3 ReceptorsSummary: 选择性M3毒蕈碱受体拮抗剂
- B1614 Solifenacin succinate中文名: 琥珀酸索非那新Target: M3 ReceptorsSummary: 毒蕈碱受体拮抗剂
- A8369 Atropine sulfate monohydrate中文名: 硫酸阿托品一水合物Target: M3 Receptors|M1 Receptors|M2 Receptors|M4 Receptors|M5 ReceptorsSummary: MAChRs拮抗剂
- A3317 Clozapine N-oxide(CNO)1 Citation中文名: 氯氮平的N-氧化物Target: DREADD LigandsSummary: Clozapine代谢产物,用于化学遗传学