Neuroscience - AChE - ETA Receptors - Trk Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B2231 Amitriptyline HCl中文名: 盐酸阿米替林Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT TransportersSummary: 血清素/去甲肾上腺素受体/5-HT4/5-HT2抑制剂
- B2075 Ambrisentan中文名: 安贝生坦Target: ETA ReceptorsSummary: ETA受体拮抗剂
- A3423 Galanthamine2 Citation中文名: 加兰他敏Target: AChESummary: 乙酰胆碱酯酶抑制剂
- A1932 (-)-Huperzine A中文名: 石杉碱甲Target: NMDA Receptors|AChESummary: NMDA受体拮抗剂/AChE抑制剂