Neuroscience - M3 Receptors - Histamine H2 Receptors - D1 and D5 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1483 Fenoldopam中文名: 非诺多泮Target: D1 and D5 ReceptorsSummary: D1样多巴胺受体部分激动剂
- B1564 Ranitidine中文名: 盐酸雷尼替丁Target: Histamine H2 ReceptorsSummary: 组胺H2受体拮抗剂
- B1485 Pergolide mesylate中文名: 甲磺酸培高利特Target: D1 and D5 Receptors|D2 ReceptorsSummary: 多巴胺能激动剂
- B1607 Otilonium Bromide中文名: 奥替溴铵Target: M3 ReceptorsSummary: AChR抑制剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂
- B1600 Darifenacin HBr中文名: 氢溴酸达非那新Target: M3 ReceptorsSummary: 选择性M3毒蕈碱受体拮抗剂
- B1614 Solifenacin succinate中文名: 琥珀酸索非那新Target: M3 ReceptorsSummary: 毒蕈碱受体拮抗剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂
- A8369 Atropine sulfate monohydrate中文名: 硫酸阿托品一水合物Target: M3 Receptors|M1 Receptors|M2 Receptors|M4 Receptors|M5 ReceptorsSummary: MAChRs拮抗剂