Metabolism - DGAT - GAPDH - Nampt - SGLT
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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- B5354 CGP 3466B maleate中文名: 奥米加匹马来酸盐Target: GAPDHSummary: GAPDH抑制剂
- A8333 Canagliflozin1 Citation中文名: 卡格列净Target: SGLTSummary: SGLT2的有效选择性抑制剂
- A3215 AZD7687Target: DGATSummary: 强效的选择性DGAT抑制剂
- A4382 A922500Target: DGATSummary: DGAT-1抑制剂
- A4381 FK866 (APO866)1 Citation中文名: 达珀利奈Target: NamptSummary: NAMPT抑制剂