Metabolism - Psoriasis Vulgaris - Pancreatic Cancer - Chronic Lymphocytic Leukemia - Diabetes
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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- B4900 Indoximod (NLG-8189)Summary: 吲哚胺2,3-双加氧酶(IDO)途径抑制剂
- B6988 BRL 50481Target: Phosphodiesterases (PDEs)Summary: PDE7抑制剂
- B1296 Glibenclamide中文名: 格列本脲Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 胰岛素生产调节剂
- A8403 CP-91149Target: Glycogen PhosphorylasesSummary: 糖原磷酸化酶选择性抑制剂
- A3893 Troglitazone中文名: 曲格列酮Target: PPARSummary: PPARγ激动剂
- A4364 Methazolamide中文名: 醋甲唑胺Target: Carbonic AnhydrasesSummary: 碳酸酐酶抑制剂
- A4362 Tioxolone中文名: 噻克索酮Target: Carbonic AnhydrasesSummary: CAI抑制剂
- A4057 AUY922 (NVP-AUY922)1 CitationTarget: HSP90Summary: Hsp90抑制剂