Membrane Transporter/Ion Channel - Voltage-gated Potassium (KV) Channels - Voltage-gated Sodium (NaV) Channels - TRP Channel - Carbonic Anhydrases
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B5515 ProTx IITarget: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.7通道阻断剂
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B2268 Amiloride HCl dihydrate中文名: 盐酸阿米洛利二水合物Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|UrokinasesSummary: 有效上皮钠通道(ENaC)阻断剂
- B1420 Bupivacaine HCl中文名: 盐酸布比卡因Target: Voltage-gated Sodium (NaV) ChannelsSummary: 麻醉药
- B2272 Phenytoin sodium中文名: 苯妥英钠Target: Voltage-gated Sodium (NaV) ChannelsSummary: 钠通道稳定剂
- B2278 Ibutilide Fumarate中文名: 富马酸伊布利特Target: Voltage-gated Potassium (KV) Channels|Voltage-gated Calcium Channels (CaV)|sodium channelSummary: III类抗心律失常药物
- B2274 Proparacaine HCl中文名: 盐酸丙美卡因Target: Voltage-gated Sodium (NaV) ChannelsSummary: 电压门控钠通道拮抗剂
- B2277 A-803467Target: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.8通道阻断剂
- B1055 IcilinTarget: TRP ChannelSummary: TRPM8/ hENaCδ激动剂