Membrane Transporter/Ion Channel - Delayed rectifier outward potassium current (IKr) - Voltage-gated Potassium (KV) Channels - GPR35 - TRP Channel
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂
- B2278 Ibutilide Fumarate中文名: 富马酸伊布利特Target: Voltage-gated Potassium (KV) Channels|Voltage-gated Calcium Channels (CaV)|sodium channelSummary: III类抗心律失常药物
- B1055 IcilinTarget: TRP ChannelSummary: TRPM8/ hENaCδ激动剂
- A8417 Dofetilide2 Citation中文名: 多非利特Target: Delayed rectifier outward potassium current (IKr)Summary: 钾通道抑制剂
- A1174 AMG-517Target: TRP ChannelSummary: TRPV1拮抗剂