MAPK Signaling - Acute Myeloid Leukemia - Non-small Cell Lung Cancer - Liver Cancer
The mitogen-activated protein kinase (MAPK) is a highly conserved family of serine/threonine kinases that mediate a board range of cellular processes, including proliferation, differentiation, motility, migration, stress response, apoptosis and survival. The activation of MAPK involves signaling pathways consisting of MAPK kinase (i.e. MAPKKK or MEKK) that activates MAPK/ERK (i.e. MAPKK or MEK). A variety of extracellular signals such as mitogens, cytokines, growth factors, and environmental stressors stimulate a phosphorylation-dependent increase in the activity of MAPK.
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
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- A1947 MEK162 (ARRY-162, ARRY-438162)中文名: 贝美替尼Target: MEKSummary: MEK1/2抑制剂
- A5801 BIX 02189Target: MEK|ERKSummary: MEK5抑制剂
- A5566 LY22288201 CitationTarget: p38Summary: p38 MAP激酶抑制剂
- A3018 Trametinib (GSK1120212)7 Citation中文名: 曲美替尼Target: MEKSummary: MEK1和MEK2抑制剂
- A3009 Sorafenib2 Citation中文名: 索拉非尼Target: Raf|VEGFRSummary: Raf激酶和酪氨酸激酶抑制剂