GPCR/G protein - NPFF receptor - LPA - Serotonin (5-HT) reuptake - CB1 Receptors
All GPCRs share a common seven trans-membrane structure. GPCRs are associated with heterotrimeric G-proteins which are GTP-binding proteins made of alpha, beta, and gamma subunits. When a ligand binds to GPCR, it activates the attached G-protein, the GDP is replaced with GTP. The activated G-protein then dissociates into an alpha and a beta-gamma complex which activates downstream signaling pathways. These intracellular signaling pathways include cAMP/PKA, calcium/NFAT, phospholipase C, protein tyrosine kinases, MAP kinases, PI-3-kinase, nitric oxide/cGMP, Rho, and JAK/STAT.
GPCRs are one of the most important therapeutic targets for various diseases, over 30% of all modern medicinal drugs target this family. Aberrant GPCR functions are involved in pathological conditions such as neurological, immunological and hormonal disorders. A large number of GPCRs have been identified, but whose ligands are not known, are classified as orphan receptors.
- B7818 ONO-7300243Target: LPASummary: LPA1拮抗剂
- B7155 BIBP 3226 trifluoroacetateTarget: NPY Receptors|NPFF receptorSummary: 混合NPY Y1和NPFF受体拮抗剂
- B1427 AM251Target: CB1 ReceptorsSummary: 有效的CB1拮抗剂
- B1429 Rimonabant3 Citation中文名: 利莫那班Target: CB1 Receptors|CB2 ReceptorsSummary: CB1 受体拮抗剂
- B1426 Org 27569Target: CB1 ReceptorsSummary: 大麻素CB1受体别构调节剂
- A2436 Fluoxetine HCl中文名: 盐酸氟西汀Target: Serotonin (5-HT) reuptakeSummary: 5-羟色胺重吸收抑制剂