DNA Damage/DNA Repair - Renal Cell Carcinoma - Multiple Myeloma - Pancreatic Cancer
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B4856 CAY10603Target: Histone Deacetylases (HDACs)Summary: HDAC6抑制剂
- B2295 Pirarubicin1 Citation中文名: 吡柔比星Target: TopoisomerasesSummary: 拓扑异构酶II抑制剂,蒽环类抗生素
- A1402 Gemcitabine HCl中文名: 盐酸吉西他滨Summary: 抑制DNA合成,脱氧胞苷类似物
- A3872 TH-302Summary: 低氧激活的前体药物,抑制H460/HT29细胞生长
- A4099 Valproic acid sodium salt (Sodium valproate)中文名: 丙戊酸钠Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4093 ITF2357 (Givinostat)2 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4083 Rocilinostat (ACY-1215)1 CitationTarget: Histone Deacetylases (HDACs)Summary: 选择性的HDAC6抑制剂
- A8178 Panobinostat (LBH589)10 Citation中文名: 帕比司他Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂