Cell Cycle/Checkpoint - Histone Acetyltransferases (HATs) - FGR - DNA-PK - FGFR
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A8626 ETP-46464Target: PI3K|mTOR|DNA-PK|ATM/ATRSummary: ATR抑制剂
- A4488 Anacardic acid中文名: 漆树酸Target: Histone Acetyltransferases (HATs)Summary: HAT抑制剂
- A4124 TAK-901Target: Aurora Kinases|FLT3|Src|JAK|LRRK2|Hck|FGR|YES|Fyn|ARGSummary: Aurora A/B抑制剂
- A4122 PHA-680632Target: Aurora Kinases|PLK|FGFRSummary: Aurora激酶抑制剂