Cell Cycle/Checkpoint - Arp2/3 complex - PKA - Rac - NTRK1/TRKA - Chk
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A3291 CCT241533Target: ChkSummary: 有效的Chk2抑制剂
- B5880 CCT244747Target: ChkSummary: CHK1抑制剂
- B3523 Fasudil中文名: 法舒地尔Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)Summary: 钙拮抗剂
- B1088 LY2606368Target: ChkSummary: CHK1抑制剂
- B1236 BML-277Target: ChkSummary: 有效的Chk2选择性抑制剂
- B1437 PF-477736Target: ChkSummary: Chk1抑制剂
- B2219 EHop-0161 CitationTarget: RacSummary: Rac1/Rac3 GTPase抑制剂
- B3058 CK-6361 CitationTarget: Arp2/3 complexSummary: Arp2/3复合体抑制剂
- A8394 CHIR-124Target: FLT3|GSK-3|Chk|PDGFRSummary: Chk1抑制剂
- A8477 MK-8776 (SCH-900776)Target: ChkSummary: Chk1高效选择性抑制剂