Proteases
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- B7854 o-Phenanthroline中文名: 1,10-菲罗啉,邻菲罗啉Summary: 金属蛋白酶抑制剂
- C5038 2-cyano-Pyrimidine中文名: 2-氰基嘧啶Summary: 组织蛋白酶K抑制剂
- C4787 EquisetinSummary: HIV-1整合酶抑制剂
- C4501 cis-ACCPSummary: IV型胶原特异性MMP-2和MMP-9抑制剂
- C4437 UCF 101Summary: Omi/HtrA2蛋白水解活性的抑制剂
- C4325 BAY-678Summary: HNE抑制剂
- C4331 MMP-13 InhibitorSummary: MMP-13抑制剂
- C4081 MMP Inhibitor IISummary: MMPs抑制剂
- C4189 Arphamenine B (hemisulfate)Summary: 氨肽酶B抑制剂
- C4021 TS 155-2Summary: 大环内酯,抑制凝血酶刺激的钙进入细胞