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TS 155-2

 
Catalog No.
C4021
大环内酯,抑制凝血酶刺激的钙进入细胞
组合的产品项目
规格价格库存 数量
1mg
¥ 4,116.00
Ship with 10-15 days
5mg
¥ 16,195.00
Ship with 10-15 days

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A

背景

TS 155-2, is a macrocyclic lactone related to hygrolidin, is produced by a different Streptomyces species found in oil. It blocks thrombin-evoked calcium (Ca2+) entry into cells. TS155-2 exerts hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity showed on the original patent, however, no literature investigation of TS155-2 is available.

A rapid increase in cytosolic Ca2+ is related to the signal transduction events following the induction of thrombin in a wide range of cell types which include fibroblasts, platelets, megakaryocytes, endothelium and smooth muscle. Thrombin-stimulated Ca2+ mobilization has been shown to be involved in both Ca2+ release from internal storage sites and Ca2+influx and has been extensively studied in human platelets. Thrombin triggers phospholipase C resulting in the rapid generation of inositol 1,4,5-trisphosphate (IP3), which elicits the release of Ca2+ from IP3-sensitive stores. However, the thrombin-induced Ca2+ influx is still an area of contention [1].

In vitro: Up to now, in vitro study of TS 155-2 is still in the development stage.

In vivo: Up to now, in vivo study of TS 155-2 is still in the development stage.

Reference:
[1].  Somasundaram, B., Mason, M., & Mahaut-Smith, M. Thrombin-dependent calcium signalling in single human erythroleukaemia cells. The Journal of Physiology.1997;501(3):485-495.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt704.9
Cas No.1314486-37-7
FormulaC39H60O11
SynonymsJBIR 100
SolubilitySoluble in DMSO
Chemical Name2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H
SDFDownload SDF
Canonical SMILESC[C@H]([C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](OC(/C=C/C(O)=O)=O)C1)[C@H](O)[C@@H]([C@](OC(/C(C)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C
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质量控制

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批次:

化学结构

TS 155-2