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MMP Inhibitor II

 
Catalog No.
C4081
MMPs抑制剂
组合的产品项目
规格价格库存 数量
1mg
¥ 1,191.00
Ship with 10-15 days
5mg
¥ 2,870.00
Ship with 10-15 days
10mg
¥ 4,116.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

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A

背景

MMP Inhibitor II is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 24 nM, 18.4 nM, 30 nM and 2.7 nM for MMP-1, MMP-3, MMP-7 and MMP-9, respectively [1].

MMPs belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. MMPs have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. These enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. In addition, MMPs exert function in metastasis by promoting tumor invasion and angiogenesis. It was shown that the expression of various members of the MMP family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. Furthermore, MMPs are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1].

In vitro: Up to now, in vitro study of MMP Inhibitor II is still in the development stage.

In vivo: Up to now, in vivo study of MMP Inhibitor II is still in the development stage.

Reference:
[1].  Slawomir M. Wojtowicz-Praga, Robert B. Dickson and Michael J. Hawkins. Matrix metalloproteinase inhibitors. Investigational New Drugs. 1997; 15: 61–75.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt513.6
Cas No.203915-59-7
FormulaC21H27N3O8S2
SynonymsMatrix Metalloproteinase Inhibitor II,NHDDPC,PG 117025,PGE 4410186
Solubility≤0.5mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Namehexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-2-pyrimidinecarboxamide
SDFDownload SDF
Canonical SMILESCOC1=CC=C(S(N2CC(C)(C)CN(S(C3=CC=C(OC)C=C3)(=O)=O)C2C(NO)=O)(=O)=O)C=C1
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

MMP Inhibitor II