MMP Inhibitor II
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MMP Inhibitor II is a potent, reversible and broad-range inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 24 nM, 18.4 nM, 30 nM and 2.7 nM for MMP-1, MMP-3, MMP-7 and MMP-9, respectively [1].
MMPs belong to a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. MMPs have been engaged in several pathological processes, including tumor growth and metastasis, arthritis, multiple sclerosis, and periodontal disease. These enzymes play a vital role in tissue repair and remodeling via degrading all the extracellular matrix components, including fibrallar and non-fibrallar collagens, laminin, fibronectin, and basement membrane glycoproteins, which enables cell migration. In addition, MMPs exert function in metastasis by promoting tumor invasion and angiogenesis. It was shown that the expression of various members of the MMP family by tumors is closely associated with their proliferative and invasive behavior and metastatic potential. Furthermore, MMPs are broadly sub-divided into three classes: stromelysins, gelatinases, and collagenases, which are secreted in a proenzyme form and require activation to digest an extracellular matrix [1].
In vitro: Up to now, in vitro study of MMP Inhibitor II is still in the development stage.
In vivo: Up to now, in vivo study of MMP Inhibitor II is still in the development stage.
Reference:
[1]. Slawomir M. Wojtowicz-Praga, Robert B. Dickson and Michael J. Hawkins. Matrix metalloproteinase inhibitors. Investigational New Drugs. 1997; 15: 61–75.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 513.6 |
Cas No. | 203915-59-7 |
Formula | C21H27N3O8S2 |
Synonyms | Matrix Metalloproteinase Inhibitor II,NHDDPC,PG 117025,PGE 4410186 |
Solubility | ≤0.5mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide |
Chemical Name | hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-2-pyrimidinecarboxamide |
SDF | Download SDF |
Canonical SMILES | COC1=CC=C(S(N2CC(C)(C)CN(S(C3=CC=C(OC)C=C3)(=O)=O)C2C(NO)=O)(=O)=O)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |