2-cyano-Pyrimidine
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5g | ¥247.00 | 现货 | |
| 10g | ¥1124.00 | 现货 |
特色产品
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
IC50: 170 nM
2-cyano-Pyrimidine is a cathepsin K inhibitor.
Cathepsin K is a protease defined by its high specificity for kinins, which is involved in bone resorption. Cathepsin K's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. Such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Therefore, inhibitors of Cathepsin K are showing great potential in the treatment of osteoporosis.
In vitro: 2-cyano-Pyrimidine was identified as a cathepsin K inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. Enzymatic study showed that 2-cyano-Pyrimidine had an IC50 value of 170 nM for inhibition of cathepsin K, elevated activity of which has been linked to the formation of osteoporosis and arthritis. Moreover, Cathepsin K was found to be a lysosomal cysteine protease found in osteoclasts. [1,2].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Altmann, E. ,Aichholz, R.,Betschart, C., et al. 2-cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K. Journal of Medicinal Chemistry 50(4), 591-594 (2007).
[2] Rankovic Z et al. Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7.
产品性质
| 物理外观 | Solid |
| CAS号 | 14080-23-0 |
| 分子式 | C5H3N3 |
| 分子量 | 124.1 |
| 小分子别名 | 2-Cyanopyrimidine |
| 化学名称 | 2-pyrimidinecarbonitrile |
| 溶解度 | insoluble in EtOH; ≥24.2 mg/mL in H2O with ultrasonic; ≥8.2 mg/mL in DMSO |
| SMILES | NCc1ncccn1 |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献,APExBIO并未验证,仅供参考)
IC50和靶点
| 生物活性描述 | 2-Cyanopyrimidine 是一种强效的非选择性半胱氨酸蛋白酶 cathepsin K 抑制剂,IC50 为 170 nM。2-Cyanopyrimidine 可用于治疗骨质疏松症。 |



沪公网安备 31011002003500