Neuroscience - AChE - Prostaglandin synthesis - 5-HT receptor
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1572 LatrepirdineTarget: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptorSummary: 脑细胞死亡抑制剂
- A8503 Piroxicam中文名: 吡罗昔康Target: COX|Prostaglandin synthesisSummary: 前列腺素合成/Cox抑制剂
- A3744 Quetiapine中文名: 喹硫平Target: AChR|adrenergic receptor|5-HT receptor|Dopamine receptor|Histamine receptorSummary: 多巴胺受体拮抗剂
- A3423 Galanthamine2 Citation中文名: 加兰他敏Target: AChESummary: 乙酰胆碱酯酶抑制剂
- A1932 (-)-Huperzine A中文名: 石杉碱甲Target: NMDA Receptors|AChESummary: NMDA受体拮抗剂/AChE抑制剂