Neuroscience - Norepinephrine transporter - 5-HT2 Receptor - Histamine H1 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A3316 Clemizole hydrochloride中文名: 盐酸克立咪唑Target: Histamine H1 Receptors|TRPC channelSummary: H1组胺受体拮抗剂
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B7072 2-Pyridylethylamine dihydrochlorideTarget: Histamine H1 ReceptorsSummary: 组胺H1受体激动剂
- B1568 Azelastine HCl中文名: 盐酸氮卓斯汀Target: Histamine H1 ReceptorsSummary: 有效的,第二代,选择性的组胺受体拮抗剂
- B1566 Rupatadine Fumarate1 Citation中文名: 富马酸卢帕他定Target: Histamine H1 Receptors|PAFRSummary: PAF和组胺(H1)受体的抑制剂
- B1563 Pemirolast potassium中文名: 吡嘧司特钾Target: Histamine H1 ReceptorsSummary: 组胺H1受体拮抗剂
- B1549 Hydroxyzine 2HCl中文名: 羟嗪二盐酸盐Target: Histamine H1 ReceptorsSummary: 组胺H1受体拮抗剂
- B1548 Cyclizine 2HCl中文名: 氧杂蒽酮Target: Histamine H1 ReceptorsSummary: 组胺H1受体拮抗剂
- B2231 Amitriptyline HCl中文名: 盐酸阿米替林Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT TransportersSummary: 血清素/去甲肾上腺素受体/5-HT4/5-HT2抑制剂
- B1547 Cetirizine DiHCl中文名: 盐酸西替利嗪Target: Histamine H1 ReceptorsSummary: H1受体反向激动剂