Neuroscience - Gap Junctions - 5-HT1 Receptor - Serotonin reuptake
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1045 Gap 274 CitationTarget: Gap JunctionsSummary: 缝隙连接阻断剂
- A1044 Gap 268 CitationTarget: Gap JunctionsSummary: 间隙连接阻断肽,对应于connexin 43的63-75 aa。
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B2251 Naratriptan中文名: 盐酸那拉曲坦,盐酸纳拉曲坦Target: 5-HT1 ReceptorSummary: 选择性5-HT1受体亚型激动剂
- B1205 Fluvoxamine中文名: 氟伏沙明Target: Serotonin reuptakeSummary: 选择性5-羟色胺再摄取抑制剂
- A8389 Carbenoxolone disodium1 CitationTarget: Gap JunctionsSummary: 11β-HSD抑制剂
- A2700 10Panx1 CitationTarget: Gap JunctionsSummary: Panx-1模拟抑制肽