Neuroscience - COX - Norepinephrine transporters - Histamine receptor
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1445 Flunixin Meglumin中文名: 氟尼辛葡甲胺Target: COXSummary: 环氧合酶抑制剂
- B1441 Lornoxicam中文名: 氯诺昔康Target: COXSummary: COX-1/COX-2抑制剂
- B1458 Lumiracoxib中文名: 罗美昔布Target: COXSummary: 新型的选择性COX-2抑制剂
- B2236 Desvenlafaxine中文名: 去甲文拉法辛Target: 5-HT Transporters|Norepinephrine transportersSummary: 5-羟色胺(5-HT)和去甲肾上腺素(NE)再摄取抑制剂
- B1447 Ketorolac tromethamine salt中文名: 酮咯酸氨丁三醇Target: COXSummary: 非选择性COX抑制剂
- B1454 Rofecoxib中文名: 罗非昔布Target: COXSummary: COX-2抑制剂
- B1459 Valdecoxib中文名: 代他考昔Target: COXSummary: COX-2抑制剂
- A8503 Piroxicam中文名: 吡罗昔康Target: COX|Prostaglandin synthesisSummary: 前列腺素合成/Cox抑制剂
- A8466 Meloxicam (Mobic)中文名: 美洛昔康Target: COXSummary: 非甾体抗炎药
- A8449 Indomethacin中文名: 吲哚美辛Target: COXSummary: Cox抑制剂