Neuroscience - AChE - 5-HT1 Receptors - 5-HT1 Receptor - Na /Ca2 Exchangers (NCXs)
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A5294 Sumatriptan Succinate中文名: 舒马普坦琥珀酸盐Target: 5-HT1 ReceptorsSummary: 5-HT1受体激动剂
- A3926 Vortioxetine中文名: 沃替西汀Target: 5-HT1 Receptors|5-HT7 Receptors|5-HT3 Receptors|SERTSummary: 5-HT受体拮抗剂
- A3811 SEA04004 CitationTarget: Na /Ca2 Exchangers (NCXs)Summary: 特异性的Na+/Ca2+交换抑制剂
- A3423 Galanthamine2 Citation中文名: 加兰他敏Target: AChESummary: 乙酰胆碱酯酶抑制剂
- A1932 (-)-Huperzine A中文名: 石杉碱甲Target: NMDA Receptors|AChESummary: NMDA受体拮抗剂/AChE抑制剂