Membrane Transporter/Ion Channel - Voltage-gated Sodium (NaV) Channels - Cell Experiments
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5515 ProTx IITarget: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.7通道阻断剂
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B1420 Bupivacaine HCl中文名: 盐酸布比卡因Target: Voltage-gated Sodium (NaV) ChannelsSummary: 麻醉药
- B2272 Phenytoin sodium中文名: 苯妥英钠Target: Voltage-gated Sodium (NaV) ChannelsSummary: 钠通道稳定剂
- B2274 Proparacaine HCl中文名: 盐酸丙美卡因Target: Voltage-gated Sodium (NaV) ChannelsSummary: 电压门控钠通道拮抗剂
- B2277 A-803467Target: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.8通道阻断剂
- A8513 Riluzole中文名: 力鲁唑Target: Voltage-gated Sodium (NaV) Channels|glutamate releaseSummary: 钠通道抑制剂
- A5354 Zonisamide中文名: 唑尼沙胺Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|Carbonic Anhydrases|Calcium-Activated Potassium (KCa) ChannelsSummary: 抗惊厥和机械效应的抗癫痫药
- A3418 Flecainide acetate中文名: 氟卡胺Target: Voltage-gated Sodium (NaV) ChannelsSummary: 抗心律失常药