Immunology/Inflammation - TBK1 - DNA Methyltransferases - COX
The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
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- B2133 Suprofen中文名: 舒洛芬Target: COXSummary: 双重COX-1/COX-2抑制剂
- A3635 MRT67307 HClTarget: TBK1|MARK1|NUAK1Summary: SIK/TBK-1/IKKe抑制剂
- A3220 Bardoxolone中文名: 巴多索隆Target: COX|iNOSSummary: 用于治疗慢性肾病,每天一次
- N1315 Parthenolide中文名: 小白菊内酯,欧苷菊Target: Histone Deacetylases (HDACs)|MDM2|DNA Methyltransferases|p53|5-HT