GPCR/G protein - Depression - Acute Kidney Injury - Melanoma
All GPCRs share a common seven trans-membrane structure. GPCRs are associated with heterotrimeric G-proteins which are GTP-binding proteins made of alpha, beta, and gamma subunits. When a ligand binds to GPCR, it activates the attached G-protein, the GDP is replaced with GTP. The activated G-protein then dissociates into an alpha and a beta-gamma complex which activates downstream signaling pathways. These intracellular signaling pathways include cAMP/PKA, calcium/NFAT, phospholipase C, protein tyrosine kinases, MAP kinases, PI-3-kinase, nitric oxide/cGMP, Rho, and JAK/STAT.
GPCRs are one of the most important therapeutic targets for various diseases, over 30% of all modern medicinal drugs target this family. Aberrant GPCR functions are involved in pathological conditions such as neurological, immunological and hormonal disorders. A large number of GPCRs have been identified, but whose ligands are not known, are classified as orphan receptors.
- B2236 Desvenlafaxine中文名: 去甲文拉法辛Target: 5-HT Transporters|Norepinephrine transportersSummary: 5-羟色胺(5-HT)和去甲肾上腺素(NE)再摄取抑制剂
- A2436 Fluoxetine HCl中文名: 盐酸氟西汀Target: Serotonin (5-HT) reuptakeSummary: 5-羟色胺重吸收抑制剂
- A3723 Phloretin中文名: 根皮素Target: SGLTSummary: 在苹果中发现的二氢查耳酮
- A3170 AM9662 CitationTarget: LPA ReceptorsSummary: LPA1拮抗剂