DNA Damage/DNA Repair - Renal Cell Carcinoma - Lung Cancer - Glioblastoma - Acute Myeloid Leukemia
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B2295 Pirarubicin1 Citation中文名: 吡柔比星Target: TopoisomerasesSummary: 拓扑异构酶II抑制剂,蒽环类抗生素
- B1476 Raltitrexed中文名: 雷替曲塞Target: Thymidylate SynthaseSummary: 胸苷酸合酶抑制剂
- B1470 Procarbazine HCl中文名: 盐酸甲基苄肼Summary: 抗肿瘤化疗药物
- B1399 Temozolomide中文名: 蒂清,替莫唑胺Summary: DNA甲基化,化疗剂
- B1963 Lomustine1 Citation中文名: 洛莫司汀Target: RNA synthesisSummary: 抗肿瘤药
- B1383 VE-8222 CitationTarget: ATM/ATRSummary: ATR抑制剂
- A2451 Epirubicin HCl中文名: 盐酸表阿霉素Target: TopoisomerasesSummary: 抗生素类抗肿瘤药物
- A1971 Etoposide4 Citation中文名: 依托泊苷Target: TopoisomerasesSummary: 拓扑异构酶II(Topo II)抑制剂
- A4090 JNJ-264815853 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A8178 Panobinostat (LBH589)10 Citation中文名: 帕比司他Target: Histone Deacetylases (HDACs)Summary: HDAC抑制剂