Cell Cycle/Checkpoint - Arp2/3 complex - Voltage-gated Sodium (NaV) Channels - FGFR - RAD51 - ARG
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B5881 RI-2Target: RAD51Summary: RAD51抑制剂
- B3058 CK-6361 CitationTarget: Arp2/3 complexSummary: Arp2/3复合体抑制剂
- A3764 RI-1Target: RAD51Summary: RAD51抑制剂
- A4124 TAK-901Target: Aurora Kinases|FLT3|Src|JAK|LRRK2|Hck|FGR|YES|Fyn|ARGSummary: Aurora A/B抑制剂
- A4122 PHA-680632Target: Aurora Kinases|PLK|FGFRSummary: Aurora激酶抑制剂