Cell Cycle/Checkpoint - Microtubules/Tubulins - VEGFR3/FLT4 - G-quadruplexes - FGFR
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B1035 Dolastatin 10中文名: 尾海兔素10Target: Microtubules/TubulinsSummary: 抗肿瘤剂
- A1630 Epothilone B (EPO906, Patupilone)中文名: 埃博霉素B,帕土匹龙Target: Microtubules/TubulinsSummary: 大环内酯物抗癌试剂
- A1493 ABT-751 (E7010)1 CitationTarget: Microtubules/TubulinsSummary: 微管聚合抑制剂,抗有丝分裂。
- A3742 Pyridostatin2 CitationTarget: G-quadruplexesSummary: 促生长停滞药物
- A3324 Colchicine中文名: 秋水仙碱Target: Microtubules/TubulinsSummary: 微管蛋白抑制剂
- A4393 Paclitaxel (Taxol)4 Citation中文名: 紫杉醇Target: Microtubules/TubulinsSummary: 抗肿瘤药
- A4122 PHA-680632Target: Aurora Kinases|PLK|FGFRSummary: Aurora激酶抑制剂
- A4130 ENMD-2076Target: Aurora Kinases|FLT3|RET|Src|VEGFR3/FLT4|NTRK1/TRKA|CSF-1R/c-FmsSummary: Aurora A/Flt3的选择性抑制剂