Alzheimer
Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more
- A1039 Amyloid Peptide (25-35) (human)1 CitationSummary: Aβ功能域
- A1038 Amyloid β-Peptide (10-20) (human)Summary: 在阿尔茨海默病中引发神经退行性病变。
- A1932 (-)-Huperzine A中文名: 石杉碱甲Target: NMDA Receptors|AChESummary: NMDA受体拮抗剂/AChE抑制剂
- A8200 DAPT (GSI-IX)6 CitationSummary: γ分泌酶抑制剂
- A8190 Semagacestat (LY450139)中文名: 司马西特Summary: γ分泌酶抑制剂