Neuroscience - PAFR - Histamine receptor - Substance P/NK1 Receptor - GABAA Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1566 Rupatadine Fumarate1 Citation中文名: 富马酸卢帕他定Target: Histamine H1 Receptors|PAFRSummary: PAF和组胺(H1)受体的抑制剂
- A1684 Aprepitant中文名: 阿瑞匹坦Target: Substance P/NK1 ReceptorSummary: P物质(SP)抑制剂
- A2917 Flumazenil中文名: 氟马西尼Target: GABAA ReceptorsSummary: 苯二氮卓拮抗剂
- A3744 Quetiapine中文名: 喹硫平Target: AChR|adrenergic receptor|5-HT receptor|Dopamine receptor|Histamine receptorSummary: 多巴胺受体拮抗剂