Neuroscience - PAFR - dopamine receptor - Glutamate (Metabotropic) Group I Receptors - 5-HT4 Receptor
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B5532 NPS 2390Target: Glutamate (Metabotropic) Group I ReceptorsSummary: I型mGlu拮抗剂
- B6569 CHPGTarget: Glutamate (Metabotropic) Group I ReceptorsSummary: mGlu5代谢型谷氨酸受体激动剂
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B1566 Rupatadine Fumarate1 Citation中文名: 富马酸卢帕他定Target: Histamine H1 Receptors|PAFRSummary: PAF和组胺(H1)受体的抑制剂
- B1198 CisaprideTarget: Voltage-gated Potassium (KV) Channels|5-HT4 ReceptorSummary: 5-HT4受体激动剂