Neuroscience - EAA receptor - P2Y Receptors - Dopamine receptor - sodium channels
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A1132 β-PompilidotoxinTarget: sodium channelsSummary: 减慢Na+通道失活。
- B6227 Kynurenic acid中文名: 犬尿酸Target: EAA receptorSummary: 广谱EAA拮抗剂
- A5183 Clopidogrel中文名: 硫酸氯吡格雷Target: P2Y ReceptorsSummary: P2Y12受体拮抗剂
- A3744 Quetiapine中文名: 喹硫平Target: AChR|adrenergic receptor|5-HT receptor|Dopamine receptor|Histamine receptorSummary: 多巴胺受体拮抗剂