Neuroscience - Voltage-gated Potassium (KV) Channels - 5-HT3 Receptors - Histamine H4 Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B7026 4-Methylhistamine dihydrochlorideTarget: Histamine H4 ReceptorsSummary: H4受体激动剂
- B2241 Ondansetron中文名: 昂丹司琼Target: 5-HT3 ReceptorsSummary: 血清素5-HT3受体拮抗剂
- B2259 VUF 10166Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- B1574 JNJ-7777120Target: Histamine H4 ReceptorsSummary: 组胺H4受体拮抗剂
- B2258 Tropisetron Hydrochloride中文名: 盐酸托烷司琼Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- B1198 CisaprideTarget: Voltage-gated Potassium (KV) Channels|5-HT4 ReceptorSummary: 5-HT4受体激动剂
- A5166 Ondansetron HCl中文名: 盐酸昂丹司琼Target: 5-HT3 ReceptorsSummary: 5-HT3受体拮抗剂
- A1334 Mosapride Citrate中文名: 莫沙必利柠檬酸盐Target: 5-HT3 Receptors|5-HT4 ReceptorsSummary: 5-HT受体激动剂
- A3926 Vortioxetine中文名: 沃替西汀Target: 5-HT1 Receptors|5-HT7 Receptors|5-HT3 Receptors|SERTSummary: 5-HT受体拮抗剂