Neuroscience - D4 Receptors - Substance P/NK1 Receptor
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1488 Pramipexole中文名: 普拉克索Target: D2 Receptors|D3 Receptors|D4 ReceptorsSummary: 多巴胺激动剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂
- A1684 Aprepitant中文名: 阿瑞匹坦Target: Substance P/NK1 ReceptorSummary: P物质(SP)抑制剂