Neuroscience - D1 and D5 Receptors - dopamine receptor - dopamine receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B1572 LatrepirdineTarget: Voltage-gated Calcium Channels (CaV)|NMDA receptor|adrenergic receptor|Histamine receptors|GluR|5-HT receptor|dopamine receptors|AMPA receptorSummary: 脑细胞死亡抑制剂
- B1483 Fenoldopam中文名: 非诺多泮Target: D1 and D5 ReceptorsSummary: D1样多巴胺受体部分激动剂
- B1485 Pergolide mesylate中文名: 甲磺酸培高利特Target: D1 and D5 Receptors|D2 ReceptorsSummary: 多巴胺能激动剂
- B1490 Quetiapine Fumarate1 Citation中文名: 富马酸奎硫平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|5-HT7 ReceptorsSummary: 多巴胺受体拮抗剂
- B2235 Clozapine中文名: 氯氮平Target: 5-HT2 Receptors|D1 and D5 Receptors|D2 Receptors|D3 Receptors|5-HT1 Receptors|D4 ReceptorsSummary: 5-HT受体拮抗剂