Neuroscience - M1 Receptors - BACE
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B6606 Telenzepine dihydrochloride中文名: 替仑西平二盐酸盐,太兰泽平二盐酸盐Target: M1 ReceptorsSummary: 毒蕈碱M1受体拮抗剂
- B1598 Biperiden HCl1 Citation中文名: 盐酸比哌立登Target: M1 ReceptorsSummary: 抗胆碱能药物
- B3224 AZD3839Target: BACESummary: BACE1有效的选择性抑制剂
- A8465 LY28867211 CitationTarget: BACESummary: BACE 抑制剂
- A8369 Atropine sulfate monohydrate中文名: 硫酸阿托品一水合物Target: M3 Receptors|M1 Receptors|M2 Receptors|M4 Receptors|M5 ReceptorsSummary: MAChRs拮抗剂