AZD3839
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AZD3839是BACE1的一种新型抑制剂，IC50值4.8μm [1]。
已报道用生化FRET分析表明AZD3839可抑制人BACE1活性。此外，AZD3839也被报道可抑制人SH-SY5Y细胞、鼠N2A细胞、小鼠和豚鼠的初级皮质神经元细胞释放sAPPβs。另外还表明AZD3839可有效地减少几内亚猪、老鼠和非人类的灵长类动物中脑脊液(CSF)、等离子体和大脑Aβ水平。AZD3839还可以减少C57BL/6小鼠初级皮层神经元（IC50 = 50.9 nmol/l）、N2A细胞(小鼠神经母细胞瘤)（IC50 = 32.2 nmol/l）和Dunkin-Hartley豚鼠初级皮层神经元（IC50 = 24.8 nmol/l）分泌Aβ40的水平[2]。
参考文献：
[1] Sparve E1, Quartino AL1, Luttgen M1, Tunblad K1, Teiling-Gardlund A1, Falting J1, Alexander R1, Kagstrom J1, Sjodin L1, Bulgak A1, Al-Saffar A1, Bridgland-Taylor M2, Pollard C3, Swedberg MD4, Vik T5, Paulsson B1. Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on Single Ascending Dose study data with AZD3839. J Pharmacol Exp Ther. 2014 Jun 10.
[2] Jeppsson F1, Eketjll S, Janson J, Karlstrm S, Gustavsson S, Olsson LL, Radester AC, Ploeger B, Cebers G, Kolmodin K, Swahn BM, von Berg S, Bueters T, Flting J. Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57.
| Storage | Store at -20°C |
| M.Wt | 449.4 |
| Cas No. | 1227163-56-5 |
| Formula | C24H15F4N5 |
| Solubility | Soluble in DMSO |
| Chemical Name | (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)-1,2-dihydroisoindol-1-amine |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC(=C1)C2(C3=C(C(N2)N)C(=CC=C3)F)C4=CC(=NC=C4)C(F)F)C5=CN=CN=C5 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | AZD3839是BACE1的一种新型抑制剂，IC50值为4.8 μM。 | |||||
| 靶点 | BACE1 | |||||
| IC50 | ||||||
化学结构
