Neuroscience - STAT - 5-HT2 Receptor - P2Y Receptors - GABAB Receptors
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B6506 SCH 23390 hydrochlorideTarget: dopamine receptor|5-HT1 Receptor|5-HT2 ReceptorSummary: 多巴胺受体拮抗剂
- B7546 ColivelinTarget: STATSummary: 神经保护肽和STAT3的激活剂
- B1531 (R)-baclofen中文名: (R)-巴氯芬Target: GABAB ReceptorsSummary: GABA受体激动剂
- A5183 Clopidogrel中文名: 硫酸氯吡格雷Target: P2Y ReceptorsSummary: P2Y12受体拮抗剂