Colivelin
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500ug | ￥1306.00 | 现货 | |
| 1mg | ￥2090.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Colivelin is a brain-penetrant neuroprotective peptide, exhibiting potent long-term capacity against Aβ deposition, synaptic plasticity deficits, and neuronal apoptosis in neurodegenerative disease. Moreover, Colivelin is an activator of STAT3, which can rescue ischemic neuronal death and axonal remodeling by activating JAK/STAT3 signaling. Thus, Colivelin has the potential for the treatment of Alzheimer’s disease and ischemic brain injury.
References:
1. Zhao H, Feng Y, Wei C, et al. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience, 2019, 416: 198-206.
2. Chiba T, Yamada M, Hashimoto Y, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. The Journal of Neuroscience, 2005, 25(44): 10252-10261.
产品性质
| 物理外观 | White lyophilised solid |
| CAS号 | 867021-83-8 |
| 分子式 | C119H206N32O35 |
| 分子量 | 2645.13 |
| 溶解度 | insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O |
| SMILES | CC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@]2([H])CCCN2C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/ |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 可利韦林（CLN）是一种脑穿透性神经保护肽，对神经退行性疾病中的Aβ沉积、神经元凋亡和突触可塑性缺陷具有强效的长期保护能力。可利韦林是 STAT3 的激活剂。 |
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