Neuroscience - Selective - COX
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B1441 Lornoxicam中文名: 氯诺昔康Target: COXSummary: COX-1/COX-2抑制剂
- B1458 Lumiracoxib中文名: 罗美昔布Target: COXSummary: 新型的选择性COX-2抑制剂
- B1459 Valdecoxib中文名: 代他考昔Target: COXSummary: COX-2抑制剂
- A8449 Indomethacin中文名: 吲哚美辛Target: COXSummary: Cox抑制剂
- A8446 Ibuprofen中文名: 布洛芬Target: COXSummary: 生物学活性
- A1664 Celecoxib中文名: 塞来昔布Target: COXSummary: COX-2选择性抑制剂