Neuroscience - Depression - Prostate Cancer
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- B2252 Paroxetine HCl1 Citation中文名: 盐酸帕罗西汀Target: 5-HT TransportersSummary: 抗抑郁药
- B1564 Ranitidine中文名: 盐酸雷尼替丁Target: Histamine H2 ReceptorsSummary: 组胺H2受体拮抗剂
- A8449 Indomethacin中文名: 吲哚美辛Target: COXSummary: Cox抑制剂
- A2436 Fluoxetine HCl中文名: 盐酸氟西汀Target: Serotonin (5-HT) reuptakeSummary: 5-羟色胺重吸收抑制剂