Membrane Transporter/Ion Channel - benzodiazepine receptor - Voltage-gated Calcium Channels (CaV) - Calcium-activated chloride channels (CaCC)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B6401 PK 111951 CitationTarget: benzodiazepine receptorSummary: 外周苯二氮卓拮抗剂
- B5351 SNX 482Target: Voltage-gated Calcium Channels (CaV)Summary: 电压依赖性R型CaV2.3钙通道阻滞剂
- B6367 NPPBTarget: Calcium-activated chloride channels (CaCC)|GPR35Summary: 氯离子通道抑制剂
- B2268 Amiloride HCl dihydrate中文名: 盐酸阿米洛利二水合物Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|UrokinasesSummary: 有效上皮钠通道(ENaC)阻断剂
- B1410 Amlodipine中文名: 氨氯地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B1393 Nitrendipine中文名: 尼群地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B2278 Ibutilide Fumarate中文名: 富马酸伊布利特Target: Voltage-gated Potassium (KV) Channels|Voltage-gated Calcium Channels (CaV)|sodium channelSummary: III类抗心律失常药物
- B1867 Verapamil HCl1 Citation中文名: 盐酸维拉帕米Target: Voltage-gated Calcium Channels (CaV)Summary: L-型钙通道阻断剂
- B1989 Nisoldipine中文名: 尼索地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻断剂
- A5354 Zonisamide中文名: 唑尼沙胺Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|Carbonic Anhydrases|Calcium-Activated Potassium (KCa) ChannelsSummary: 抗惊厥和机械效应的抗癫痫药