Membrane Transporter/Ion Channel - Voltage-gated Potassium (KV) Channels - Glutamate (EAAT) Transporters - Voltage-gated Calcium Channels (CaV) - GABAB Receptors
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B5086 CGP 55845 hydrochlorideTarget: GABAB ReceptorsSummary: GABAB受体拮抗剂
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B5351 SNX 482Target: Voltage-gated Calcium Channels (CaV)Summary: 电压依赖性R型CaV2.3钙通道阻滞剂
- B2268 Amiloride HCl dihydrate中文名: 盐酸阿米洛利二水合物Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|UrokinasesSummary: 有效上皮钠通道(ENaC)阻断剂
- B1410 Amlodipine中文名: 氨氯地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B1393 Nitrendipine中文名: 尼群地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B2278 Ibutilide Fumarate中文名: 富马酸伊布利特Target: Voltage-gated Potassium (KV) Channels|Voltage-gated Calcium Channels (CaV)|sodium channelSummary: III类抗心律失常药物
- B1867 Verapamil HCl1 Citation中文名: 盐酸维拉帕米Target: Voltage-gated Calcium Channels (CaV)Summary: L-型钙通道阻断剂
- B1989 Nisoldipine中文名: 尼索地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻断剂
- B1531 (R)-baclofen中文名: (R)-巴氯芬Target: GABAB ReceptorsSummary: GABA受体激动剂