Membrane Transporter/Ion Channel - Voltage-gated Potassium (KV) Channels - F1 Fo-ATPase - Voltage-gated Sodium (NaV) Channels - Inward Rectifier Potassium (Kir) Channels - Voltage-gated Calcium Channels (CaV)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B7659 Psora 41 CitationTarget: Voltage-gated Potassium (KV) ChannelsSummary: Kv1.3阻断剂
- B5515 ProTx IITarget: Voltage-gated Sodium (NaV) ChannelsSummary: NaV1.7通道阻断剂
- B5351 SNX 482Target: Voltage-gated Calcium Channels (CaV)Summary: 电压依赖性R型CaV2.3钙通道阻滞剂
- B7590 Quinidine中文名: 奎尼丁Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)Summary: 降低Na+和K+通道电流
- B2268 Amiloride HCl dihydrate中文名: 盐酸阿米洛利二水合物Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|UrokinasesSummary: 有效上皮钠通道(ENaC)阻断剂
- B1410 Amlodipine中文名: 氨氯地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B2198 Nateglinide中文名: 那格列奈Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 胰岛素促分泌剂
- B1420 Bupivacaine HCl中文名: 盐酸布比卡因Target: Voltage-gated Sodium (NaV) ChannelsSummary: 麻醉药
- B1393 Nitrendipine中文名: 尼群地平Target: Voltage-gated Calcium Channels (CaV)Summary: 钙通道阻滞剂
- B2195 Gliclazide中文名: 格列齐特Target: Inward Rectifier Potassium (Kir) ChannelsSummary: 钾通道抑制剂