Membrane Transporter/Ion Channel - cAMP - Gap Junctions - NTPDases - mitochondrial pyruvate carrier (MPC)
Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
- B7113 PSB 06126Target: NTPDasesSummary: NTPDase 3抑制剂
- B2194 Tolbutamide中文名: 甲苯磺丁脲Target: cAMP|Sulfonylurea receptorsSummary: 第一代钾通道阻滞剂
- A3899 UK-50991 CitationTarget: Monocarboxylate transporters (MCTs)|mitochondrial pyruvate carrier (MPC)Summary: MCTs和MPC抑制剂
- A2700 10Panx1 CitationTarget: Gap JunctionsSummary: Panx-1模拟抑制肽