DNA Damage/DNA Repair - telomerase - FPTase - O6-methylguanine-DNA-methyl-transferase (MGMT) - RNA synthesis
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B1963 Lomustine1 Citation中文名: 洛莫司汀Target: RNA synthesisSummary: 抗肿瘤药
- A1945 BIBR 15322 CitationTarget: telomeraseSummary: 端粒酶新型的选择性抑制剂
- A3327 Costunolide中文名: 木香烃内酯Target: FPTase|TelomerasesSummary: BMM分化抑制剂
- A1912 Lomeguatrib中文名: 罗米鲁曲Target: O6-methylguanine-DNA-methyl-transferase (MGMT)Summary: MGMT抑制剂