DNA Damage/DNA Repair - telomerase - HSV - RNA synthesis - DNA Alkylating
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
- B1809 Penciclovir中文名: 喷昔洛韦Target: HSVSummary: HSV-1 DNA合成抑制剂
- B1963 Lomustine1 Citation中文名: 洛莫司汀Target: RNA synthesisSummary: 抗肿瘤药
- A8644 Acyclovir中文名: 阿昔洛韦Target: HSVSummary: 抗病毒剂
- A2097 Ifosfamide中文名: 异环磷酰胺Target: DNA AlkylatingSummary: 细胞抑制剂
- A2197 Dacarbazine中文名: 达卡巴嗪Target: DNA AlkylatingSummary: 抗肿瘤(恶性黑色素瘤和肉瘤)
- A1945 BIBR 15322 CitationTarget: telomeraseSummary: 端粒酶新型的选择性抑制剂