Penciclovir
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Penciclovir是一种HSV-1 DNA合成抑制剂[1].
Penciclovir是一种鸟嘌呤衍生物,被用作抗疱疹病毒药物.Penciclovir具有与阿昔洛韦相似的抗性谱.在斑块还原试验中,penciclovir表现出对HSV-1\HSV-2和VZV的抑制活性,IC50值分别为0.4 μg/ml\1.5 μg/ml和3.1 μg/ml.该物质对CMV也有最低的活性.在MRC-5细胞中,penciclovir可抑制HSV-1复制,IC99值为0.4 μg/ml.此外,penciclovir在Vero细胞中对HSV-1和HSV-2具有持久的抗病毒活性.除此之外,penciclovir在HSV-1感染的MRC-5细胞中可被磷酸化形成三磷酸形式.Penciclovir三磷酸是实际上抑制疱疹病毒复制的代谢产物.Penciclovir抑制HSV-1 DNA合成的IC50值为0.16 μM,并不影响细胞DNA合成[1,2].
参考文献:
[1] Boyd M R, Bacon T H, Sutton D, et al. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl) guanine (BRL 39123) in cell culture. Antimicrobial agents and chemotherapy, 1987, 31(8): 1238-1242.
[2] Hodge R A, Perkins R M. Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrobial agents and chemotherapy, 1989, 33(2): 223-229.
Storage | Store at -20°C |
M.Wt | 253.26 |
Cas No. | 39809-25-1 |
Formula | C10H15N5O3 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥11.95 mg/mL in DMSO |
Chemical Name | 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one |
SDF | Download SDF |
Canonical SMILES | C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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